RNA Biology Research Laboratory

ABOUT RBRL

Research at RNA Biology Research Laboratory is concentrated on identification of novel gene regulatory mechanisms operating in mammalian cells that are primarily executed by small regulatory RNA- the microRNA. We explore the mechanisms that regulate microRNAs levels and activities in mammalian immune, neuronal and cancer cells. The major goal of our research is to identify the machineries that either by regulating the intra and extracellular transport of microRNAs or by modifying microRNA interacting proteins affects the microRNA function in mammalian cells. Contributions of subcelluar structures and organelles in compartmentalization of miRNAs biogenesis, function and turnover in mammalian cells is also explored under this research aim. Alteration in miRNA-machinery upon exposure of mammalian cells to pathogens and its implications in the disease process is the other major thrust area of our research.